Effects of 4-aminopyridine in Eaton Lambert Syndrome.
نویسندگان
چکیده
The effects of 4-aminopyridine (a non-anticholinesterase antagonist of curare-like agents) on the evoked muscle action potentials (EMAP) in a patient with Eaton Lambert Syndrome are reported. On two separate occasions the i.v. administration of 0.31 mg kg(-1) and 0.62 mg kg(-1) was followed by a 300% increase of EMAP for about 2 h without serious side-effects.
منابع مشابه
Novel drug of choice in Eaton-Lambert syndrome.
Sir: Muscle weakness in the myasthenic syndrome of Eaton-Lambert' is caused by diminished transmitter release from motor nerve endings2 secondary to morphological destruction of the active release zones in the nerve terminals3 which is thought to have an autoimmune aetiology."5 Immunosuppressive therapy has recently been recommended5 but its full effect is delayed by several months and severe s...
متن کاملEaton-Lambert syndrome: a clinical and electrophysiological study of a patient treated with 4-aminopyridine.
In a patient with the Eaton-Lambert syndrome, 4-aminopyridine produced temporary improvement of clinical and electromyographic abnormalities. Application of the drug in vitro to intercostal muscle from the patient produced an increase in the evoked release of neurotransmitter from intramuscular nerves.
متن کامل[Eaton-Lambert syndrome].
In the myasthenic syndrome sometimes associated with bronchogenic carcinoma (Eaton-Lambert syndrome) muscular weakness is caused by reduced acetylcholine release from motor nerve terminals (Elmqvist and Lambert, 1968). Guanidine is a potent drug in this condition (Lambert, 1966) but serious adverse reactions have been reported (Lambert and Howard, 1972; Cherington, 1976; Henriksson et al., 1977...
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Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they are widely used to treat different neurological disorders. Here we present a patient with idiopathic downbeat nystagmus and lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia who was treated with the sustained-release form of 4-aminopyridine (4-AP). During ...
متن کاملEaton-Lambert Syndrome Associated with Pituitary Apoplexy
A case of Eaton-Lambert syndrome associated with pituitary apoplexy is presented. It is thought to be the first reported case. The clinical features, electrophysiological findings and effects and side effects of therapeutic drugs are noted. Endocrinological dysfunctions are discussed in relation to pituitary disorder.
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ورودعنوان ژورنال:
- British journal of anaesthesia
دوره 50 4 شماره
صفحات -
تاریخ انتشار 1978